30 SEENA MAGOWITZ FOUNDATION While Phil ultimately succumbed to the disease in January of 2018, he didn’t go without first giving his all to the fight against it. “Your outcome will be determined by how you approach the disease, not by how others who have gone before you have fared,” Phil once said, with his own approach to fighting the disease proving to be one of bravery, hope and dedication. He told others facing similar battles that they should always consider clinical trials, because, while they grant you access to cutting-edge treatment meth - ods and medications that are otherwise unavail - able, they also give you the opportunity to play a real, tangible role in the advancement of science — and in prolonging the lives of pancreatic cancer fighters everywhere. To help ensure that even more people battling pancreatic cancer have the resources, financial and otherwise, to participate in clinical trials, Phil’s wife launched Phil’s Fund in partnership with HonorHealth in 2019. While doing so helped her keep Phil’s legacy alive, it also helped eliminate some of the financial hurdles that prevent so many patients from pursuing exploratory care. “We knew a clinical trial was the right move when we recognized that it presented the only real chance we had at prolonging Phil’s life,” Kathy said. “After a devastating diagnosis, it was the first time we truly felt hope.” Legacy Heroes

It is a pleasure to put into words what you have meant to me personally and to all of those who have been affected by your work. It is easy to rattle off the list of therapeutic agents that you helped develop that have resulted in approval by the FDA. Agents such as gemcitabine, irinotecan, nab-paclitaxel, nanoliposomal irinotecan among others. The big impact of this has been in the individuals with cancer whose lives have improved. I don’t know how to best measure the impact of living longer with cancer but every wedding anniversary, birthday, degree attainment, child or grandchild’s graduation counts beyond any way we can measure and without your work these milestones would be missed. One of your gifts to the world has been your impact as a mentor. You have mentored so many physicians and scientists over the years and they all carry your legacy through their work. It seems to me every other individual has had some professional relationship with you that has impacted them in a positive way. The ability to collaborate with others to do more cannot be understated. With all of your accomplishments over the years it would be easy be aloof and set in your ways of doing things but you continue to seek out other like-minded individuals who want to do more not only for pancreatic cancer but for so many malignancies. I’ll never forget when I first met you – you said “Hi I’m Dan” and you constantly chided me for calling you Dr. Von Hoff insisting we are colleagues. Every day I’m trying to live up to be your colleague. And finally I would be remiss to speak of you as a physician at the bedside. Your insights over the years have not only led to the development of new therapies but have helped countless others in managing individuals better. I was floored to find out you were the one responsible for the observation of dose dependent cardiac toxicity of doxorubicin- every single fellow in oncology in the world is taught that. Your observations both in the clinic and in the lab and in discussions with your colleagues have led to the aforementioned breakthroughs. The ability to take all that information and being able to apply to patient care is the ultimate definition of a physician. So Dr. Von Hoff or Dan- I thank you for being my friend, my mentor, and my colleague. I look forward to continuing to work with you in improving patients’ lives. Erkut Borazanci M.D., M.S. Medical Oncology/Clinical Investigator | HonorHealth Research Institute Clinical Associate Professor, Clinical Translational Research Division TGen Clinical Assistant Professor, Internal Medicine | University of Arizona College of Medicine, Phoenix Dear Dan, Erkut I don’t know how to best measure the impact of living longer with cancer but every wedding anniversary, birthday, degree attainment, child or grandchild’s graduation counts beyond any way we can measure and without your work these milestones would be missed.