Building on this three-drug foundation, a new study is underway at HonorHealth Research Institute, adding a synthetic Vitamin D and an Immunotherapy drug called Nivolumab to the Triple Trial. A BUSY LIFE WITH CAREFUL FOLLOW-UP Dr. Varma comes to Scottsdale every three months to see his medical oncologist, Erkut Borazanci, M.D., who also is a clinical investigator at HonorHealth Research Institute and medical director of the institute’s early cancer detection program and to see Daniel Von Hoff, M.D., one of the world’s leading pancreatic cancer researchers with TGen. Every month, through his oncologist in Indiana, his tumor marker is evaluated. In between visits, he has been traveling and working during this, his sabbatical year through the university. He has gone to University of California Santa Barbara and to ETH Zurich in Switzerland — a science, technology, engineering and mathematics university that has produced 21 Nobel laureates — to research and present seminars. Beginning in November and continuing until next March, he will be based at the University of California at Los Angeles. “I’m extremely grateful to be able to continue working and researching during my entire treatment,” Dr. Varma said. “And I urge anyone with a family history of cancer to undergo genetic testing. If any mutations are discovered, your health can be closely monitored, and in many cases, disease can be detected earlier than it might have been otherwise” Legacy Heroes

Dr. Von Hoff is an inspiration to current and future generations of researchers and has dedicated his life to fighting Pancreatic Cancer. His continued, selfless dedication to his research – and his desire to teach others – has significantly impacted the lives of countless individuals and their families. We are honored to have supported Dr. Von Hoff’s efforts and will continue to do so at every opportunity in the future. Keep up the good fight, Dan. ISSAC provides tailored Artificial Intelligence solutions leveraging our VOR AI™ platform. We believe the next major advancement in humanity will be based on the undiscovered knowledge currently residing in the massive amounts of data collected every day. We know every data set has a story to tell. WE HELP YOU FIND YOUR HIDDEN STORY! “It is not because things are difficult that we do not dare; it is because we do not dare that things are difficult.” — Seneca ISSAC Corp | 6760 Corporate Drive, Suite 240 | Colorado Springs, Colorado 80919 (719) 725-6900 | www.issaccorp.com